Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor). Hydroxychloroquine kidney function Raynauds and hydroxychloroquine How do you take Plaquenil? You take Plaquenil as a pill 1 or 2 times a day. Take the pills with food or milk. Your body weight will tell your doctor what dose is safe for you. What to do if you forget to take your Plaquenil. If you miss a dose of Plaquenil, do not make it up or double your next dose. Wait until the next scheduled time, and take. It may take several weeks or months to see improvement if you are taking this for lupus or arthritis. Hydroxychloroquine may not prevent malaria in all cases. If you are also taking a certain drug for diarrhea kaolin or taking antacids such as magnesium/aluminum hydroxide, take hydroxychloroquine at least 4 hours before or after these products. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Contact your doctor right away if you have any changes to your heart rhythm. When is the best time to take hydroxychloroquine Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Hydroxychloroquine Oral Uses, Side Effects, Interactions, Pictures. Interactions between plaquenil and methotrexatePlaquenil and ovarian cancerAdverse effects of hydroxychloroquineHydroxychloroquine water retention Re best time to take plaquenil. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months. Best time to take plaquenil - HealthBoards. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Side-effects, uses, time to work. Thanks Jodie, I always take it with a meal. I have High BP and also atrial tachycardia and take two tablets for those conditions wich I take at the same time as the Hydroxychloroquine. I just wondered if perhaps I should separate them and take the Hydroxychloroquine in the evening to see if that would help. I have to take mine separate and each time with food. Otherwise they make me really sick and nauseous too. I take most of my meds spaced out through the day 4x per day now down from 6x and with food in order to minimize the side effects and get the junk in me. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area.