Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Side effects of long term plaquenil use Toxic retinopathy plaquenil Major Depression is #139 concern in Plaquenil discussions. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil for depression Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, Plaquenil Side Effects Common, Severe, Long Term - Plaquenil 200 mg tablet adalah Plaquenil and Depression - a real-world study. Summary Depression is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain. Will you have Depression with Plaquenil - eHealthMe. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. So glad you posted this and I now know I'm not the only one having the crazy reaction to Plaquenil. I have RA and was put on Plaquenil 1 week ago and noticed the extreme moods swings, frustration turning to extreme rage, feeling crazy, then crying over my reactions. Hydroxy Plaquenil CAN affect moods & can cause 'mental changes' in some people u should b able 2 clarify this by reading u're info leaflet in the med packet. I came off hydroxy as I gained no benefit whatsoever & apart from getting near on every side effect from it, became the most s**** bitch ever lol!