Pharmacokinetics of quinine chloroquine and amodiaquine

Discussion in 'Canada Pharmacy Online' started by Cерегин, 25-Feb-2020.

  1. ReD-Dragon New Member

    Pharmacokinetics of quinine chloroquine and amodiaquine


    It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles.

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    The effect of a single 600 mg oral dose of quinine on the pharmacokinetics of a 200 mg oral dose of carbamazepine was studied in 6 healthy volunteers.40 Compared with giving carbamazepine alone, quinine administration increased the carbamazepine area under the plasma concentration-time curve AUC and peak plasma concentration 51% and 36.5%, respectively. Chloroquine CQ, a 4-aminoquinoline compound, has been used for the prophylaxis and treatment of malaria. It acts on the ring forms of the parasites, which are relatively resistant to the action of quinine 23. Effects of food on the pharmacokinetics of amodiaquine in healthy volunteers. chloroquine, quinine, sulfadoxine, pyrimethamine, artesunate, acetaminophen and salicylate. The method is.

    People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes.

    Pharmacokinetics of quinine chloroquine and amodiaquine

    Quinine Pharmacology Your Complete Guide to Quinine., Pharmacokinetics of Hydroxychloroquine and Its Clinical.

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  7. It is the first-line treatment for P. falciparum complicated malaria and is a treatment option for P. falciparum uncomplicated malaria in chloroquine-resistant regions. 25–27 Quinine seems to act against Plasmodium spp. by inhibiting haem polymerase that leads to toxic haem levels. 27 Quinine metabolism is interesting because acute malaria influences absorption, the binding-protein fraction, CYP450 activity and excretion of quinine.

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    At day 28, parasitological failure was 14, 11, 3, and 0% in the women assigned chloroquine, sulfadoxine+pyrimethamine, amodiaquine, and amodiaquine with sulfadoxine+pyrimethamine, respectively. General weakness, vomiting, dizziness, and nausea were the most frequent adverse effects and were more common in those who took amodiaquine and amodiaquine with sulfadoxine+pyrimethamine than in those who took sulfadoxine. Abstract. Obesity can modify the pharmacokinetics of lipophilic drugs. As quinine is a lipophilic drug, this study was conducted to determine whether the pharm Many, like chloroquine, amodiaquine, mefloquine, and quinine act on heme in the parasitic food vacuole. In this way, they prevent the polymerization of hemoglobin, which can be toxic to the plasmodium parasite. Others are folate antagonists. Some of the drugs in this class, like pyrimethamine and proguanil.

     
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    Hydroxychloroquine Side Effects, Dosage, Uses, and More Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.

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