I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil 300 mg Side effects of plaquenil pms Difference between chloroquine and quinine Azulfidine Sulfasalazine is used to treat moderate to severe inflammatory bowel conditions. It's also used with other medicines to treat rheumatoid arthritis. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Three patients in the three-drug group, 18 in the sulfasalazine–hydroxychloroquine group, and 16 in the methotrexate group were considered to have had treatment failures. The remaining patients in each group discontinued the study because of toxic effects or protocol violations. A total of 195 drugs are known to interact with sulfasalazine 40 major drug interactions 183 brand and generic names 148 moderate drug interactions 581 brand and generic names I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine vs plaquenil Any success with plaquenil or sulfasalazine? PsoriaticArthritis, Treatment of Rheumatoid Arthritis with Methotrexate Alone. Cheap aralen 250 An important and much‐studied group of patients with RA is the group who have had only a partial or a suboptimum response to MTX. A number of studies have enrolled this type of patient and have randomized patients to receive active therapy or placebo in addition to their baseline MTX therapy 9, 11, 13-15. Treatment of rheumatoid arthritis with methotrexate and.. Sulfasalazine Compared to Alternatives -. Taking plaquenil and sulfasalazine Arthritis Information. Compare Methotrexate vs Sulfasalazine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Sulfasalazine rated 5.7/10 in overall patient satisfaction. Plaquenil hydroxychloroquine and Azulfidine EN-tabs sulfasalazine delayed release tablets are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding.