Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil sulfate uses Plaquenil for psa Hydroxychloroquine dose dialysis The following case studies illustrate examples where Plaquenil administration was associated with either new onset psoriasis or flaring of pre-existing psoriasis. Case 1. A middle-aged woman sought another opinion for a puzzling rash which had been seen by two dermatologists. At first, skin biopsies showed features of eczema. Subsequent biopsies Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Antimalarial agents were first used for lupus in 1894 when Payne treated a case of discoid lupus with quinine. It was not until 1951 that Page reported the benefits of quinacrine for lupus. The use of hydroxychloroquine for the cutaneous manifestations of DM were first described by Woo et al in 1984. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil skin rash Hydroxychloroquine Plaquenil, Plaquenil Side Effects Common, Severe, Long Term - Plaquenil and erectile dysfunction I got this after about 5 weeks, mine was a blistery rash and it was only on my shoulders, upper chest and upper back. My doctor said it was photodermatitis and caused from a sensitivity to the sun caused by the plaquenil. Rash from plaquenil DailyStrength. Adverse Cutaneous Reactions to Hydroxychloroquine Are More.. Hydroxychloroquine Skin Support. Applies to hydroxychloroquine compounding powder, oral tablet. Cardiovascular. Frequency not reported Cardiomyopathy can result in fatal cardiac failure, biventricular hypertrophy. Dermatologic-Pigmentary changes in skin and mucous membranes, bleaching of hair, and alopecia are usually reversible when therapy is discontinued. I wonder if the commencement of the skin rashes and itching is related in some way to this decreased effectiveness of the medication too. So far from the other posts it may seems that Plaquenil may be somehow associated with skin rash that looks like small hives and patchy itchiness. View detailed reports from patients taking Hydroxychloroquine Sulfate who experienced rash. Reports are from official medical reports as well as online extractions from user reviews and forum discussions.