Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine and early pregnancy Plaquenil and ibuprophen Also, a concentration-dependent inhibition of chloroquine was obtained with prodigiosin-treated DNA. Chloroquine is an intercalating agent that unwinds DNA, resulting in a decrease in negative superhelicity and thus in the negative superhelical free energy activity. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. Chloroquine could also be acting directly on DNA, altering the expression of Plasmodium genes. Early work on this drug has shown that chloroquine can act as DNA-intercalating agent 19 and this mechanism was used to explain the antimalarial effect of the drug 20. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine intercalating Chloroquine - FDA prescribing information, side effects., Chloroquine Indications, Side Effects, Warnings - Hydroxychloroquine dose for ra Chloroquine Aralen is used for preventing and treating malaria and amebiasis, an infection of the intestines caused by a parasite. Chloroquine Aralen - Side Effects, Dosage, Interactions. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Background The anti-malarial chloroquine can modulate the.. Chloroquine with Anti-Viral Drugs - Hepatitis B - MedHelp. Chloroquine, like other intercalators, may work by altering three-dimensional structure. For exam- ple, there is evidence that DNA may form left-handed helices Z-DNAin transcriptionally active regions. We have found that chloroquine prevents the transition of DNA to the Z form in vitro, at concentrations as low as 20 Ref. 17. Rheumatoid Arthritis What Is Chloroquine Aralen? Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne. Antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggest-ing that these compounds act against parasites by intercalating into their DNA. Key words antimalarial agents; quinomycin A; DNA intercalation Malaria is one of the most serious infectious diseases in many tropical and subtropical countries. Due.