I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Plaquenil lower platelets Chloroquine food cravings Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Check the latest outcomes from 50,877 Plaquenil users, or browse all drugs. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Check the latest outcomes from 339,740 Methotrexate users, or browse all drugs. Plaquenil vs. Methotrexate side effect and effectiveness comparison. Summary We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Plaquenil vs methotrexate Member Discussions and Questions Advice Needed for., Plaquenil vs. Methotrexate side effect and effectiveness. 400mg plaquenil at nightPlaquenil and pulmonary hypertensionPlaquenil and grapefruitOsteoarthritis joint nodules hydroxychloroquine Interaction between Methotrexate and Plaquenil There is no known interaction between Methotrexate and Plaquenil in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Compare Methotrexate vs Plaquenil for RA - Comprehensive.. Plaquenil vs. Methotrexate side effect and. Plaquenil vs Methotrexate Antineoplastics Cancer drugs.. Hi Everyone, I went to my Rheumatologist last week. She is giving me and my gastro. dr. a choice between Plaquenil and Methotrexate. One affects your eyes more and one affects your liver more. That is what my dr. said. So, what do yall know about the side effects of both and the benefits of both? I would appreciate any Answer. Both drugs are well tolerated and useful in patients with lupus associated arthritis. Its difficult to comment directly on your situation. In general, most rheumatologists including myself use Plaquenil before MTX for lupus arthritis. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset.