Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine maculopathy treatment Can plaquenil help mononucleosis Hydroxychloroquine side effects diarrhea Thirty eyes with HCQ retinopathy were followed with SD-OCT after drug cessation. Findings before disruption of the parafoveal EZ included parafoveal outer nuclear layer ONL thinning, disruption of the parafoveal interdigitation zone, and reduced reflectivity of the parafoveal EZ. SD-OCT images may have important implications to use as an early indicator of retinal toxicity without any visible signs of hydroxychloroquine retinopathy. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Hydroxychloroquine retinopathy oct Eye screening for patients taking hydroxychloroquine Plaquenil, Effect of Hydroxychloroquine on the Retinal Layers A. Plaquenil treatment for scleroderma Unfortunately, in some people with more advanced retinopathy, stopping hydroxychloroquine treatment does not prevent the disease from getting worse. At the. Plaquenil - RCOphth. Retinal Physician - Hydroxychloroquine Maculopathy An.. Optical Coherence Tomography Protocols for Screening of.. Mar 10, 2017 Spectral-domain OCT SD-OCT is a widely available technology that permits objective, structural evaluation of the macula in patients at risk of HCQ retinopathy. Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. OCT. The classic retinal toxicity has been described as “bull's-eye maculopathy,” with the appearance of a ring of parafoveal RPE depigmentation.