Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine cellular toxicity Chloroquine dose india Plaquenil toxicity in macular oct layer changes Mg 310 mg base to 600 mg 465 mg base PO daily, administered as a single daily dose or in 2 divided doses. Do not exceed 600 mg/day 465 mg base/day or 6.5 mg/kg/day 5 mg base/kg/day, whichever is lower. Let's dive in. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. Based on the 2011 recommendations from the AAO and ACR, 17% of the patients were receiving an HCQ overdose that was more than 10% above the recommended dosage, and another 13% received a smaller overdose. If the 2016 dosage guidelines were applied, the extent of overdosing might be even greater, Dr. Koppikar said. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. What is the maximum dose of plaquenil Hydroxychloroquine Side Effects, Dosage, Uses, and More, Daily Plaquenil Dosage - Crunching Numbers — Can plaquenil help to relieve neuropathy painWhat are the side effects of taking hydroxychloroquinePlaquenil and mucinexHow does plaquenil help ra The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Despite Plaquenil dosing recommendations, retinal toxicity.. Hydroxychloroquine dosage recommendations often ignored.. Hydroxychloroquine - Wikipedia. In 2016, a revised version of the guidelines recommended a maximum dose of 5 mg/kg based on actual weight, with an examination at baseline and repeat screening — via optical coherence tomography. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs.