This type of malaria medication consists of two different drugs, one called chloroquine phosphate and one called proguanil hydrochloride, that are taken as two separate tablets but are packaged together. The two drugs are taken in combination to be more effective against malaria and as a form of malaria treatment, by inhibiting the reproduction of the parasites responsible for causing malaria. Signs of plaquenil toxicity Chloroquine and proguanil vs malarone Can plaquenil cause eye damage Chloroquine proguanil medication is used to prevent and treat malaria. This type of malaria medication consists of two different drugs, one called chloroquine phosphate and one called proguanil hydrochloride, that are taken as two separate tablets but are packaged together. For patients with CrCl less than 30 mL/min, atovaquone-proguanil is contraindicated for prophylaxis of plasmodium falciparum malaria. It may be used with caution for the treatment of malaria in patients with severe renal impairment CrCl less than 30 mL/min, only if the benefits of the 3-day regimen outweigh the potential risks associated with increased drug exposure. Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Gabon All Chloroquine P. falciparum 90%, P. malariae, P. ovale, P. vivax 10% combined In some countries, chloroquine proguanil medication requires a prescription, and in other places it is available without a prescription, but it is recommended to consult a doctor before taking any malaria medication. Both these drugs can have serious side effects, especially when taken together, including itching, skin rash, stomach pain, bloody stool, and hair loss. Chloroquine-proguanil malaria prophylaxis Atovaquone / Proguanil Dosage Guide with Precautions -, Atovaquone / Proguanil Dosage Guide with Precautions. Mylan generic plaquenilChloroquine dose for rheumatoid arthritisChloroquine 250 mg tabTaking plaquenil over 2 yearsPlaquenil drug side effects Mefloquine, taken to prevent malaria may increase the risk of convulsions or fits when taken at the same time as chloroquine. Levothyroxine thyroid medicine. Medicines used to treat epilepsy, as chloroquine may reduce their effectiveness. Chloroquine & Proguanil Anti-Malarial Tablets. CDC - Malaria - Travelers - Malaria Information and.. Boots Chloroquine & Proguanil Anti-Malarial Tablets - Drug.. In a double-blind equivalence trial, 1083 participants travelling to a malaria-endemic area were randomly assigned to two treatment groups atovaquone-proguanil plus placebos for chloroquine and proguanil, or chloroquine, proguanil, and placebo for atovaquone-proguanil. Jun 15, 2004 Major exclusion criteria included pregnancy and/or lactation, travel to an area where prophylaxis with chloroquine-proguanil would be inappropriate, a history of active malarial infection within 12 months of screening, and travel to an area where malaria is endemic within 60 days of screening. Design and procedures. In The Travel and Tropical Medicine Manual Fifth Edition, 2017. Author recommendations For travelers to areas with known or potential chloroquine-resistent malaria with a predominance of Plasmodium falciparum or Plasmodium vivax, clinicians should prescribe any of the following malaria preventive drugs mefloquin, doxycycline, chloroquine-proguanil, or atovaquone-proguanil.