Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine uses other than malaria Chloroquine injection intravenous Hydroxychloroquine pulmonary toxicity Aralen mechanism of action Hydroxychloroquine HCQ is frequently used to treat autoimmune diseases, especially systemic lupus erythematosus SLE. Although its exact mechanism of action in autoimmune diseases is not completely understood, we do know that HCQ has many benefits and plays a key role in the management of many diseases. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid The observation of neutropenia and enhanced neutrophil-induced tissue damage in patients with SLE is difficult to reconcile. One possibility is that a proportion of the neutrophils that infiltrate organs are actively undergoing NETosis or apoptosis, which could contribute to promotion of neutropenia but also to organ damage and immune. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil autoimmune neutropenia Plaquenil Uses, Dosage & Side Effects -, PATIENT FACT SHEET Hydroxychloroquine Plaquenil Malaria treatment drugs chloroquineHydroxychloroquine vision side effects Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed. Taking Plaquenil for Rheumatoid Arthritis. Neutrophils in the pathogenesis and manifestations of SLE. Neutropenia low neutrophil count Causes - Mayo Clinic. This article is a review of different management strategies for the hematological manifestations of systemic lupus erythematosus SLE, the strategies include immunosuppressive drugs, some noval therapies and B-cell depletion for refractory thrombocytopenia in patients with SLE and in antiphospholipid antibody syndrome associated with SLE. The results of their study, however, suggested an autoimmune mechanism for neutropenia in patients with SLE.9. Rustagi et al,11 in a study of 18 patients with SLE, suggested complement-activating antineutrophil IgG autoantibodies existed in SLE and their presence correlated with neutropenia. The neutrophil-binding IgG was 2–3 times higher. Can Plaquenil cause Neutropenia? Neutropenia is a known side effect of Plaquenil. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences.