Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Hydroxychloroquine sulfatr alcohol Saliva drug test rx hydroxychloroquine false positive drug test I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Hochberg MC, Tracy JK, Hawkins-Holt M, Flores RH 2003 Comparison of the efficacy of the tumour necrosis factor α blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis. Ann Rheum Dis 62Suppl 2ii13–ii16 PMC free article Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate or plaquenil Methotrexate vs Plaquenil Comparison -, Perioperative Management of Medications Used in the. Chloroquine mechanism of action autophagy Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Compare Methotrexate vs Plaquenil -. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Effects of methotrexate and hydroxychloroquine combination.. Plaquenil and Rheumatrex and Trexall belong to different drug classes. Plaquenil is an antimalarial medication and Rheumatrex and Trexall are antimetabolite drugs. Side effects of Plaquenil and Rheumatrex and Trexall that are similar include nausea, vomiting, dizziness, or headache. Jun 09, 2006 Hochberg MC, Tracy JK, Hawkins-Holt M, Flores RH 2003 Comparison of the efficacy of the tumour necrosis factor α blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis. Ann Rheum Dis 62Suppl 2ii13–ii16 PMC free article Interaction between Methotrexate and Plaquenil There is no known interaction between Methotrexate and Plaquenil in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice.