Listing a study does not mean it has been evaluated by the U. Hydroxychloroquine may inactivate these pathways and results in the death of pancreatic cancer cells. Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Hydroxychloroquine and liver What other drug can you take with plaquenil Targeting autophagy in cancer. Jean M. Mulcahy Levy Jean M. Mulcahy Levy is an assistant professor in the Department of Pediatrics and the Department of Pharmacology at the University of Colorado School of Medicine, USA. They turned to an autophagy inhibitor called hydroxychloroquine and a drug that blocks a protein in the MAPK pathway. In mice transplanted with KRAS -mutant human pancreatic tumors, treatment with both drugs together slowed tumor growth and extended survival more than either drug alone. Abstract. Purpose We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination Patients received 600 mg hydroxychloroquine orally twice per day. Patients remained on treatment indefinitely without the occurrence of disease progression, unacceptable adverse events, patient withdrawal, or discontinuation per MD decision. Patients received 400 mg hydroxychloroquine orally twice per day. Patients remained on treatment indefinitely without the occurrence of disease progression, unacceptable adverse events, patient withdrawal, or discontinuation per MD decision. Hydroxychloroquine autophagy pancres Research progress of hydroxychloroquine and autophagy., Hitting an Elusive Target in Pancreatic Cancer - National. Will plaquenill make you stutterHydroxychloroquine plaquenil for malaria protectionIs plaquenil used toNabumetone lupus hydroxychloroquine Hydroxychloroquine may prevent autophagy, a normal process in which a cell destroys proteins and other substances which may lead to cell death. Autophagy may prevent normal cells from developing into tumor cells, but it may also protect tumor cells by destroying anticancer drugs or substances taken up by them. Clinical Trials Using Hydroxychloroquine - National Cancer.. A Randomized Phase II Preoperative Study of Autophagy.. Adding Hydroxychloroquine to Chemo Fails to Improve OS in.. Pancreatic ductal adenocarcinoma PDAC is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. Autophagy, a cancer cell survival mechanism whereby damaged organelles, proteins and other intracellular components are recycled, appears to be critical for NET formation in pancreatic cancer. Furthermore, the autophagy inhibitor chloroquine inhibits NET formation 13, 14.