Synthesis of chloroquine phosphate slideshare

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    Synthesis of chloroquine phosphate slideshare


    One of these ways consists of reacting 3-chloroaniline with ethoxymethylenmalonic ester to make (3-choroanilino)-methylenemalonic ester (37.1.1.4), which then undergoes high-temperature heterocyclization to make the ethyl ester of 7-chloro-4-hydroxyquinolin-3-carboxylic acid (37.1.1.5). Hydrolyzing this with sodium hydroxide gives 7-chloro-4-hydroxyquinolin-3-decarboxylic acid (37.1.1.6), which when heated at 250–270 C is decarboxylated, forming 7-chloro-4-hydroxyquinoline (37.1.1.7).

    How long should you take hydroxychloroquine Plaquenil hair loss Can i take hydroxychloroquine while pregnant Plaquenil and rapid heartbeat

    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Among the antimalarial drugs chloroquine is commonly used. • Pyrimethamine, sulfones, & tetracyclines are slower acting, less effective, & nearly always used in combination with other antimalarial drugs • The artemisinins are potent and fast-acting antimalarials with no clinical evidence of resistance. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length.

    Alkaline hydrolysis of the ethyl ester of the 7-chloro-4-hydroxyquinolin-2-carboxylic acid (37.1.1.9) and subsequent high-temperature decarboxylation of the resulting acid (37.1.1.11) gives 7-chloro-4-hydroxyquinolin (37.1.1.7). Treating this with phosphorus oxychloride gives one of the desired components for synthesis of chloroquine – 4,7-dichloroquinoline (37.1.1.1) [The second method of preparing of 4,7-dichloroquinoline (37.1.1.1) consists of reacting 3-chloroaniline with the diethyl ester of oxaloacetic acid in the presence of acetic acid to give the corresponding enamine (37.1.1.8), which when heated to 250 °C undergoes heterocyclization to the ethyl ester of 7-chloro-4-hydrozyquinolin-2-carboxylic acid (37.1.1.9) accompanied with a small amount of 5-chloro-4-hydroxyquinolin-2-carboxylic acid (37.1.1.10), which is separated from the main product by crystallization from acetic acid.

    Synthesis of chloroquine phosphate slideshare

    A New Synthesis of Chloroquine Journal of the American., Antimalarial drugs - SlideShare

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  7. Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Chloroquine phosphate tablets are an antimalarial and amebicidal drug.

    • Chloroquine - FDA prescribing information, side effects..
    • Chloroquine Phosphate - WebMD.
    • Chloroquine phosphate Sigma-Aldrich.

    The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Can we get chloroquine from 4-amino-7-chloroquinoline 7-chloroquinolin-4-amine by adding 4-chloro-N,N-diethylpentan-1-amine $\ce{CH3CHClCH23NEt2}$ ? Stack Exchange Network Stack Exchange network consists of 175 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their. [email protected] This feature is not available right now. Please try again later.

     
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    La hidroxicloroquina pertenece a una clase de medicamentos llamados antimaláricos. Plaquenil - Información del medicamento, indicaciones. Qué es la Hidroxicloroquina? El medicamento que podría. Síndrome de Sjögren - Diagnóstico y tratamiento - Mayo Clinic
     
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    Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.

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