Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Calcium and plaquenil Abnormal hydroxychloroquine visual fields Plaquenil depressione Eye And Drug Toxicity - authorSTREAM Presentation. Is retinal toxicity by chloroquine and hydroxy chloroquine related to Stargardt disease Am J of Ophthalmol 1316. Chemically, it is 7-chloro-4- 4- diethylamino-1-methylbutylaminoquinoline phosphate 12 andhas the following structural formula C 18 H 26 ClN 3.2H 3 PO 4 Molecular Weight 515.87 Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. OverviewMedical useAdverse effectsInteractionsOverdosePharmacology Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine toxicity in eye ppt Ophthal examination of eye - SlideShare, Chloroquine - FDA prescribing information, side effects and uses Plaquenil and dementiaPlaquenil blood thinnerPlaquenil geneticCan metoprolol and plaquenil be taken togetherPlaquenil pulmonary sarcoidosis Mechanism of chloroquine retinal toxicity. There is evidence that chloroquine reacts strongly with nucleic acids and nucleopro-teins.4 Thisprovidesa plausibleexplanation for chloroquine localization in tissues but does not explainits affinityfor the rod and cone cells. The histology resembles that of several other mechanisms selectively. Histopathology of Chloroquine Retinal Toxicity. Hydroxychloroquine - Wikipedia. Ocular drug toxicity - Good Hope eye clinic. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Many reports on chloroquine retinopathy exist. In contrast, only a few cases of hydroxychloroquine toxicity have been reported. Pathophysiology Chloroquine has an affinity for pigmented melanin-containing structures, which may explain its toxic properties in the eye. Melanin serves as a free-radical stabilizer and as an agent that can bind toxins. Jul 30, 2019 The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia.