Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine and skin darkening Plaquenil and ativan Hydroxychloroquine sulfa allergy Hydroxychloroquine‐induced hyperpigmentation. 2012-10-01 Dear Editor, Antimalarial agents, including chloroquine and hydroxychloroquine, have been used for the treatment of various rheumatoid diseases and skin disease through their anti‐inflammatory and immune‐modulating properties. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti- inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Pigmentation appeared after a median duration of hydroxychloroquine treatment of 32 months with a median cumulative dose of 361 g. Overall, two patients reported that the appearance of pigmented lesions was preceded by the occurrence of ecchymotic areas following microtrauma. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine hyperpigmentation treatment Hydroxychloroquine Uses, Dosage & Side Effects -, Drug-induced hyperpigmentation DermNet NZ Anti malarial medication hydroxychloroquineEye dr for plaquenilPlaquenil and liver enzymes Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine-induced hyperpigmentation in systemic.. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Hydroxychloroquine Plaquenil is not a new therapy. It has been used in rheumatology for decades and it's proven a very useful medication. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti- spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9.