It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Plaquenil myasthenia gravis Plaquenil side effects vaginal Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Despite optimization of renin-angiotensin-aldosterone system RAAS inhibition, patients with immunoglobulin A nephropathy IgAN and persistent proteinuria remain at risk for kidney failure. We evaluated the efficacy and safety of hydroxychloroquine HCQ, an immunomodulator, when added to the treatment regimen of patients with IgAN. The normal range of serum creatinine is 0.6 to 1.5 mg/dL, and the value for a given patient is relatively fixed in the absence of a change in renal function. About 90% of the daily production of creatinine is excreted through glomerular filtration and the remainder by tubular secretion. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and creatinine GFR, Kidney Fuction & Creatinine Levels DailyStrength, Effects of Hydroxychloroquine on Proteinuria in IgA. Plaquenil safer than fluoroquinolonesChloroquine systemic lupus erythematosusSle lupus and plaquenilChloroquine phosphate 250 mg dayRheumatoid arthritis chloroquine Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. BUN-to-creatinine Ratio - an overview ScienceDirect Topics. Elevated BUN and Creatine levels -. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Background and objectives Hydroxychloroquine is widely used in patients with rheumatoid arthritis. However, large-scale studies examining the long-term effects of hydroxychloroquine on the development of kidney disease in patients with rheumatoid arthritis are lacking. We aimed to assess the long-term association of hydroxychloroquine use with the risk of developing CKD in this population. Protective Effect of Hydroxychloroquine on Renal Damage in Patients with Lupus Nephritis Data from LUMINA, a Multiethnic U. S. Cohort. Creatinine was measured at the laboratories of the participating institutions by the modified method of Jaffe in which creatinine combines with picrate in an alkaline solution to form a creatinine-picrate.