In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Chloroquine resistance mechanism nbme 18 Plaquenil storage water or fat soluble Hydroxychloroquine and doxycycline Reticulocytes chloroquine Jan 15, 2020 Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil pigmentation Hydroxychloroquine Plaquenil, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil and coumadin interactionPlaquenil and shortness of breathMethotrexate and hydroxychloroquine for rheumatoid arthritis Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. The Risk of Retinal Toxicity with Plaquenil. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Lichen planus pigmentosus Genetic and Rare Diseases.. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. However, trauma and bruising may faciliate the developement of pigmentation. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. What causes drug-induced skin pigmentation? Several mechanisms may be involved in the drug-induced changes of pigmentation of the skin. Certain heavy metals, such as iron, silver, and gold, may be deposited in the dermis following damage to dermal vessels. If deposited in sufficient quantities a distinctive change in skin colour may be seen without any significant increase in melanin.