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    Doctor just tried me on a low dose of Zoloft (sertraline, an SSRI) for the anxiety, but it's making me extremely constipated. He said to give it 2 weeks for side effects to subside, but I'm on day 9 and wondering if I should bother continuing if this is how my body reacts to this drug. I'm not looking for suggestions about treating constipation, but more like, does anyone know if a side effect like that is indicative of how I react to this drug generally (in which case I'll stop taking it), or could it actually go away in two weeks? Because of my IBS and sensitivity to trapped gas, constipation is pretty much the worst side effect possible for me. Are serotonin levels in the brain and peripheral serotonin levels actually related to each other? I don't think serotonin itself crosses the blood-brain barrier. Do you know if the gut actually uses the same reuptake mechanism that's SSRIs target in the brain? My copy of Michael Gershon's 'The Second Brain' (about serotonin in the gut) is in a removal box so I can't look it up, however from what I remember the reuptake mechanism is similar, hence antidepressants resulting in constipation. In care homes and institutions, staff are trained to keep a tab of how often the inmates pass stools, to avoid fecal impaction, bowel obstruction. Many doctors will systematically prescribe a laxative with an antidepressant. What to Keep in Mind If Your Doctor Prescribes Zoloft - Verywell Mind azithromycin aristo Prescription Medication Must–Haves for IBS - IBS Center. Zoloft and constipation - PaleoHacks
     
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