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    Given the similar efficacy of tamoxifen and anastrozole for women older than age 60 years, decisions about treatment should be informed by the risk for serious adverse health effects and the symptoms associated with each drug. the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-35 trial, performed in women who had received lumpectomy plus whole-breast irradiation, anastrozole significantly improved the breast cancer–free interval, although the benefit was limited to patients aged the IBIS-II DCIS trial, performed in women who had undergone local excision with or without radiotherapy, anastrozole was noninferior to tamoxifen in preventing overall disease recurrence. Margolese, MD, of Jewish General Hospital, Mc Gill University, is the corresponding author of the NSABP B-35 article in . (For more coverage on these two trials from the 2015 San Antonio Breast Cancer Symposium, see pages 24 and 25.) NSABP B-35 Trial In this double-blind trial, 3,104 patients from 333 sites in the United States, Canada, and Mexico were randomized between January 2003 and June 2006 to receive daily anastrozole at 1 mg (n = 1,552) or tamoxifen at 20 mg (n = 1,552) for 5 years. Reduced Recurrence With Anastrozole Median follow-up was 9.0 years, with a total of 212 breast cancer–free interval events observed. Events occurred in 90 patients in the anastrozole group vs 122 in the tamoxifen group (hazard ratio [HR] = 0.73, = .78). Five-year breast cancer–free interval rates were 96.3% in both groups, and estimated 10-year rates were 93.1% vs 89.1%. Among all events, invasive disease occurred in 43 vs 69 patients (HR = 0.62, Adverse Events Second primary cancers occurred in 107 patients in the anastrozole group vs 102 in the tamoxifen group (risk ratio [RR] = 1.04, 95% confidence interval [CI] = 0.78–1.37), with a nonsignificantly greater incidence of uterine cancer in the tamoxifen group (8 vs 17 cases, RR = 0.47, 95% CI = 0.18–1.15). Fracture was nonsignificantly more common with anastrozole (69 vs 50 patients, RR = 1.38, 95% CI = 0.95–2.03). Arimidex vs Tamoxifen Comparison - amoxicillin high dose Breast Cancer Arimidex vs. Tamoxifen - WebMD Arimidex or Tamoxifen Reduce Recurrence Risk After DCIS.
     
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