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Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. In November of this past year the executive board of the Records of Early English Drama approved my proposal to develop a new large-scale, long-range collaborative endeavour called REED London. The reason why I think that this nascent project offers a valuable perspective in talking about how we keep the “H” in DH is because the project is to its very bones a HUMANITIES project that can only exist in a DIGITAL realm. We, as pre-modern performance and theatre historians, are using digital methods to aggregate its materials, access and analyze a remarkably broad array of archival documents, and amplify their importance to a broader spectrum of humanities scholars and potential collaborators than we cannot have been able to do through more traditional means. REED London develops from the Records of Early English Drama, an international scholarly project that has for the last thirty-five years worked to locate, transcribe, and edit historical documents that contain evidence of drama, secular music, and other communal entertainment and ceremony in England, Wales, and Scotland from the Middle Ages until 1642, when the Puritans closed the London theatres. REED has published twenty-seven collections of records in print comprising 36 volumes - over 17,000 pages of transcribed records plus invaluable contextual materials. A further 25 collections are planned or in progress. Since 2003, REED has recognized the importance of developing online access to archival materials as well as the creation of new born-digital resources: these include the Patrons and Performances website, the Early Modern London Theatre database, the Fortune Theatre Records digital edition, the Anglo-Latin Wordbook as well as fully searchable, open access digital editions of all of those forthcoming REED collections launching in early 2017 with Staffordshire’s dramatic records. 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