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Prednisone definition

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    Prednisone definition


    Prednisone is a medication designed to prevent the release of substances in the body that can cause inflammation, thereby lowering redness and swelling. It can treat low corticosteroid levels, or other conditions in patients with normal corticosteroid levels, such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders. Prednisone can also be used to treat the symptoms of certain types of cancer. It is sometimes used with antibiotics to treat a certain type of pneumonia in patients with HIV/AIDS. Prednisone is available as a tablet, a liquid, and a concentrated solution, designed to be taken orally. Dosing and schedule depends entirely on the patient and the condition being treated. The NIH recommends discussing any grapefruit and grapefruit juice intake with your doctor, as it can affect the absorption of the medication. buy cialis online united states Prednison gehört zu den nicht-halogenierte Glukokortikoiden. Es ist eine Vorstufe (Prodrug) von Prednisolon und wird in der Leber in die metabolisch aktive Substanz umgewandelt. Prednison kann im Allgemeinen bei allen Erkrankungen eingesetzt werden, bei denen das körpereigene Immunsystem überreagiert, z. Prednison wird oral oder intravenös verabreicht und ist 12 bis 36h wirksam. Hydrocortison bezogene, glukokortikoide Potenz beträgt 4, die relative mineralokortikoide Potenz 0,6. Damit gehört es zu den mittellang wirksamen Glukokortikoiden.

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    A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the. azithromycin 1000 mg single dose Prednisone definition a chemical derivative, CHO, of cortisone, but with fewer side effects, used in the treatment of arthritis and certain allergic and inflammatory. Prednisone is a medication designed to prevent the release of substances in the body that can cause inflammation, thereby lowering redness.

    Es kann dadurch bei vielen Erkrankungen eingesetzt werden, bei denen das Immunsystem ursächlich beteiligt ist (Autoimmunerkrankungen), eine Entzündungsreaktion des Körpers nicht erwünscht ist (etwa Asthma oder Allergie) oder z. zur Verhinderung einer Abstoßungsreaktion nach Organtransplantation. Außerdem wird Prednison im Rahmen der Chemotherapie verschiedener Krebsarten (z. Akute lymphatische Leukämie, Hodgkin-Lymphom, Non-Hodgkin-Lymphom) eingesetzt. Prednison wurde in den frühen 1950er Jahren von Arthur Nobile, einem Mitarbeiter der Firma Schering-Plough/USA, entdeckt und 1955 von der amerikanischen Arzneimittelbehörde FDA zugelassen. Anfang der 1960er Jahre wurde Prednison unter dem Markennamen Meticorten vertrieben. Wenn Prednison länger als sieben Tage eingenommen wird, kommt es zur Einschränkung der körpereigenen Produktion der Glukokortikoide in der Nebenniere und zur Abhängigkeit von der künstlichen Prednisonzufuhr. Aus diesem Grund sollte Prednison nicht abrupt abgesetzt werden, wenn die Behandlung länger als 1–2 Wochen andauert, sondern die Dosis muss langsam reduziert werden. Diese Entwöhnung dauert meist nur wenige Tage nach einer kurzfristigen Prednison-Einnahme, kann aber nach einer Langzeitbehandlung Wochen oder sogar Monate dauern. Abrupter Prednison-Entzug kann zu lebensbedrohlichen Zuständen führen, die mit der Addison-Krankheit verwandt sind (Addison-Krise). Severe inflammation; immunosuppression Adults: Dosage individualized based on diagnosis, severity of condition, and response. Amphotericin B, mezlocillin, piperacillin, thiazide and loop diuretics, ticarcillin: additive hypokalemia Aspirin, other nonsteroidal anti-inflammatory drugs: increased risk of GI discomfort and bleeding Cardiac glycosides: increased risk of digitalis toxicity due to hypokalemia Cyclosporine: therapeutic benefits in organ transplant recipients, but with increased risk of toxicity Erythromycin, indinavir, itraconazole, ketoconazole, ritonavir, saquinavir: increased prednisone blood level and effects Hormonal contraceptives: impaired metabolism and increased effects of prednisone Isoniazid: decreased isoniazid blood level Live-virus vaccines: decreased antibody response to vaccine, increase risk of adverse effects Oral anticoagulants: reduced anticoagulant requirements, opposition to anticoagulant action Phenobarbital, phenytoin, rifampin: decreased prednisone efficacy Salicylates: reduced salicylate blood level Somatrem: inhibition of somatrem's growth-promoting effects Theophylline: altered pharmacologic effects of either drug Drug-diagnostic tests. CNS: headache, nervousness, depression, euphoria, personality changes, psychosis, vertigo, paresthesia, insomnia, restlessness, seizures, meningitis, increased intracranial pressure CV: hypotension, hypertension, vasculitis, heart failure, thrombophlebitis, thromboembolism, fat embolism, arrhythmias, shock EENT: posterior subcapsular cataracts (especially in children), glaucoma, nasal irritation and congestion, rebound congestion, sneezing, epistaxis, nasopharyngeal and oropharyngeal fungal infections, perforated nasal septum, anosmia, dysphonia, hoarseness, throat irritation (all with long-term use) GI: nausea, vomiting, abdominal distention, rectal bleeding, esophageal candidiasis, dry mouth, esophageal ulcer, pancreatitis, peptic ulcer GU: amenorrhea, irregular menses Hematologic: purpura Metabolic: sodium and fluid retention, hypokalemia, hypocalcemia, hyperglycemia, decreased carbohydrate tolerance, diabetes mellitus, growth retardation (in children), cushingoid effects (with long-term use), hypothalamic-pituitary-adrenal suppression (with systemic use longer than 5 days), adrenal suppression (with high-dose, long-term use) Musculoskeletal: muscle weakness or atrophy, myalgia, myopathy, osteoporosis, aseptic joint necrosis, spontaneous fractures (with long-term use), osteonecrosis, tendon rupture Respiratory: cough, wheezing, bronchospasm Skin: rash, pruritus, contact dermatitis, acne, striae, poor wound healing, hirsutism, thin fragile skin, petechiae, bruising, subcutaneous fat atrophy, urticaria, angioedema Other: bad taste, increased or decreased appetite, weight gain (with long-term use), facial edema, aggravation or masking of infections, hypersensitivity reaction Drug-drug. • Hypersensitivity to drug, other corticosteroids, alcohol, bisulfite, or tartrazine (with some products) • Systemic fungal infections • Live-virus vaccines (with immunosuppressant doses) • Active untreated infections (except in selected meningitis patients) Use cautiously in: • diabetes mellitus, glaucoma, renal or hepatic disease, hypothyroidism, cirrhosis, diverticulitis, nonspecific ulcerative colitis, recent intestinal anastomoses, inflammatory bowel disease, thromboembolic disorders, seizures, myasthenia gravis, heart failure, hypertension, osteoporosis, hypothyroidism, ocular herpes simplex, immunosuppression, emotional instability • pregnant or breastfeeding patients • children under age 6. Calcium, potassium, thyroid I uptake, thyroxine, triiodothyronine: decreased levels Cholesterol, glucose: increased levels Nitroblue tetrazolium test for bacterial infection: false-negative result Drug-herbs. Alfalfa: activation of quiescent systemic lupus erythematosus Echinacea: increased immune-stimulating effects Ephedra (ma huang): decreased drug blood level Ginseng: potentiation of immunomodulating effect Licorice: prolonged drug activity Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers Check for signs and symptoms of depression and psychosis. • Assess blood glucose level carefully in diabetic patient.

    Prednisone definition

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  7. Apr 3, 2010. Top definition. Prednisone. "Don't mind her. she's all jacked up on prednisone". "Damn, this prednisone is making me hungry !" "I love my.

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    Looking for online definition of prednisone in the Medical Dictionary? prednisone explanation free. What is prednisone? Meaning of prednisone medical term. buy cialis pills Prednisone meaning an artificial steroid = a medicine that helps to control inflammation in the body. Learn more. Prednisone definition, an analogue of cortisone, C21H26O5, used as an anti- inflammatory, immunosuppressive, and antineoplastic in the treatment of various.

     
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