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    Retin-A, also known as tretinoin or retinoic acid, is a naturally occurring, acidic form of vitamin A. It’s part of a large class of chemical compounds called retinoids, which are used in medicine to regulate cell growth. Of the many retinoids on the market, both natural and synthetic, Retin-A is the most commonly recommended by dermatologists for the treatment of acne, wrinkles, and skin damage. This is likely due to the fact that it is the most potent, and that its effects are well documented. UV radiation is one of the major contributing factors to accelerated skin aging. As there is substantial scientific evidence to support its effectiveness, Retin-A is approved by the FDA for the clinical treatment of photodamaged skin. “Tretinoin is very effective in reversing the photo damage that has already occurred, and also in protecting against future damage,” says Dr. Kappel, a board-certified dermatologist based in Newport Beach, CA . “It also helps in the prevention of skin cancer and pre-cancers.” Retin-A is available in three different prescription strengths, 0.025%, 0.05%, and 0.1%, and can be purchased as a cream, gel, or micro-emulsion. buy clomid and nolvadex australia Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is a formulation containing 0.1% or 0.04%, by weight, tretinoin for topical treatment of acne vulgaris. This formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Other components of this formulation are purified water, carbomer 974P (0.04% formulation), carbomer 934P (0.1% formulation), glycerin, disodium EDTA, propylene glycol, sorbic acid, PPG-20 methyl glucose ether distearate, cyclomethicone and dimethicone copolyol, benzyl alcohol, trolamine, and butylated hydroxytoluene. Chemically, tretinoin is all- trans -retinoic acid, also known as (all- E )-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. It is a member of the retinoid family of compounds, and a metabolite of naturally occurring Vitamin A. Tretinoin has the following structure: Tretinoin is a retinoid metabolite of Vitamin A that binds to intracellular receptors in the cytosol and nucleus, but cutaneous levels of tretinoin in excess of physiologic concentrations occur following application of a tretinoin-containing topical drug product. Although tretinoin activates three members of the retinoid acid (RAR) nuclear receptors (RAR(alpha), RAR(beta), and RAR(gamma)) which may act to modify gene expression, subsequent protein synthesis, and epithelial cell growth and differentiation, it has not been established whether the clinical effects of tretinoin are mediated through activation of retinoic acid receptors, other mechanisms, or both. Mode of Action: Although the exact mode of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization.

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    According to the instructions, Retin-A 0,1 accelerates the maturation of skin cells lining the excretory portions of hair follicles. Collecting, these cells overlap the bulb outlet and block the outflow of gland secretions, resulting in inflammation on the skin. External, apply to the affected area in a very thin layer (the gel and cream are applied with a finger, lotion and solution with a cotton swab) one time a day in the evening before going to bed, left on the skin for 6 hours, after which it is necessary to wash with running water; if necessary, the multiplicity of the application is increased up to two times a day. For people with light and dry skin, the exposure time of the remedy at the beginning of treatment is 30 minutes, then it can be gradually increased. During the treatment, it is allowed to carefully remove completely softened comedones and pustules. The duration of treatment depends on the type of pathology: in the treatment of vulgar acne the therapeutic effect comes in 2-3 weeks, in most cases – in 6-7 weeks; the best clinical result is achieved after three months of therapy; when treating adverse events from exposure to sunlight – after 4-24 weeks. Treatment of flat warts begins with weak concentrations of tretinoin, in the absence of clinical effect, both the concentration of the remedy and the frequency of its use are increased (in the absence of skin irritation phenomena). VITACID Retinol 0.1 Cream for Antiaging, acne, wrinkles, and scars treatment. Vitacid retinol 0,1% cream works with the active red blood cells in your skin to remove acne and wrinkles and provide lasting relief against unwanted dry, rough patches and tiny bumps that may appear. This product should be applied once a day, prior to sleep onto the affected area, whilst avoiding contact with the mouth and eyes. The product contains active Retinol to soothe and calm inflamed skin restoring its natural elasticity and youthfulness. This product is not suitable for pregnant women, or those intending to get pregnant a month prior or after intended use. Always consult with a registered health professional and the included packaging prior to use to confirm your suitability. Keep out of reach of children and store at room temperature.

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