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Treating acne with Retino-A cream Retino-A cream 0.05% contains Retin, a topical treatment for acne (pimples and blackheads) that works by blocking the hardening processes of the outer skin layer (keratinisation and cornification) and increasing the shedding of old hardened skin cells, while at the same time promoting growth of new skin cells, which speeds up the turnover of skin cells, clears up pimples and blackheads and reduces the spread of acne. Retino-A cream for age spots Retino-A cream 0.05% contains Retin, a topical treatment that can help reduce visible signs of ageing on the face by lightening age spots, pigmented patches of skin caused by sun damage and general aging, common in people over 55 years. 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