OTC and prescription drug mascots may play a larger-than-expected role in patients’ health care decisions. The United States and New Zealand are the only countries in the world that currently allow direct-to-consumer (DTC) advertising. Taking advantage of the opportunity, US drug manufacturers spent $3.4 billion on advertising for the top 10 brand-name prescription drugs last year. The FDA oversees drug advertising to ensure that all ads are truthful, balanced, and accurately communicated. However, the agency does not have a say over pharmaceutical mascots. Throughout the years, these mascots have ranged from abrasive germs to cute creatures that offer solutions in a soothing tone. 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